"EXTRAORDINARY"
Is the opinion of a noted professor of
Orthopedic Surgery, Emeritus, at Harvard University.

IAGH means Intra-Articular Growth Hormone Treatment

IAGH can help you AVOID TOTAL JOINT SURGERY

   IAGH is a Stem Cell Method that grows real Joint Cartilage. It does this by regrowing the fetal cartilage skeleton in an adult's joint.
   This is important because because real joint cartilage is a remnant of the fetal cartilage skeleton!  So to replace real joint cartilage you need to re-grow a portion of the fetal skeleton. That would seem impossible. And it was until Dr. Dunn discovered IAGH, the discovery the Harvard professor called extraordinary.  IAGH is the only method which can regrow that portion of the fetal skeleton which is articular cartilage. All the other attempts to repair cartilage cannot.
   These other attempts at repair are
MICRO-FRACTURE, DRILLING, MOSAICPLASTY, CARTICEL AND CARTICEL IN MATRIX. THESE OTHER METHODS PRODUCE FIBROCARTILAGE.
UNFORTUNATELY FIBROCARTILAGE LASTS ONLY A SHORT TIME AND IS NOT A GOOD JOINT SURFACE.


   IAGH PRODUCES REAL JOINT CARTILAGE. IT COULD LAST AS LONG AS THE ORIGINAL CARTILAGE.

IAGH SCIENCE: The IAGH process rejuvenates adult blood vessels in your joint to form fetal vessels. These fetal vessels produce your own (Autologous) stem cells which then form cartilage cells (Chondrocytes). These new cartilage cells produce a new cartilage surface in your joint. This process has been published in a peer reviewed journal: "Morphoangiogenesis - a Unique Action of Growth Hormone", Allan R. Dunn, M.D., Microvascular Research Vol. 63 pages 295 - 303, 2002.


   IAGH patients have osteoarthritis of the knees, hips, ankles, shoulders, or elbows, wrists and thumbs. Some IAGH patients have rheumatoid arthritis. All patients are placed on a protocol which includes intra-articular injections of HGH and an exercise program. Patients need to avoid weight bearing on hips, knees and ankle during IAGH treatment.
Patients with rheumatoid arthritis require concurrent treatment with an anti-TN Factor, such as Enbrel FOR SUCCESSFUL RESULTS IN RHEUMATOIDS.

Questions patients frequently ask are answered here:

  1. What is the success rate of IAGH treatment?
    Based on significant measurable increase in motion, decrease of pain, and increase of joint space, the following percentages give some idea of the success rate:
    • Ankles 95%
    • Knees 86%
    • Hips over 50%
    • Elbows 95%
    • Shoulders 75%
    • Thumbs 75%

  2. What are the beneficial effects of IAGH treatment?
    Decrease or complete abatement of pain, swelling, heat and stiffness in the treated joint. Measurable increase in the space between the bone surfaces. The bone on bone condition often improves and space re-appears - up to a 4 millimeters between the bones. Several patients have been followed over five (5) years, and their symptoms have not recurred. In several cases of osteoarthritis of the knee, the bow-legged deformity was reversed and the alignment of their knees WAS restored to normal.

  3. Do you need to continue receiving IAGH injections?
    Some patients require booster injections of IAGH ONCE A YEAR OR ONCE EVERY 2 YEARS, OR NOT AT ALL.

  4. What are the side effects of the IAGH treatment?
    There were a few side effects and they were mild and reversible. There has RARELY been pain or swelling at the injection site.
    TOTAL JOINT SURGERY CAN HAVE SERIOUS COMPLICATIONS SUCH AS INFECTIONS, DEEP VEIN THROMBOSIS, PULMONARY EMBOLISM, and DEATHS.
    None of these complications occur with IAGH treatment .

  5. What is the COST OF IAGH TREATMENT:
    IAGH TREATMENT COSTS THE COST OF TOTAL JOINTS!! A TOTAL KNEE CAN COST OVER $35,000.00. IAGH TREATMENT OF THE SAME KNEE COULD COST LESS THAN $10,000.00 WHICH INCLUDES ARTHROSCOPIC SURGERY, ANY MEDICATIONS, AND rHGH.

  6. What happens if the treatment does not work?
    Nothing. You are no different than when you started treatment. No patient was made worse by IAGH treatment. Nothing happens to your joint that would prevent a total joint replacement.

  7. WHAT IS rHGH?
    rHGH is X pure HUMAN growth hormone approved by the FDA. rHGH means recombinant HUMAN GROWTH HORMONE. It is made in laboratories. Several well known pharmaceutical companies manufacture rHGH. rHGH is pure and free of all viruses. rHGH has been manufactured for several years and is approved by the FDA for several uses, such as making short children grow to normal size. It has not yet been FDA approved for injection in joints, which is an "off-label" use.

  8. WHAT IS "OFF-LABEL" USE OF A MEDICATION?
    The use of rHGH to grow new cartilage in joints is an "off-label" use. This means that an FDA approved hormone can be used for other than the FDA approved uses if the physician believes the medication is beneficial for a patient. Dr. Dunn believes that IAGH injection is very beneficial for patients with arthritis and joint injuries.

Treating Hips with IAGH:
Dr. Dunn is constantly IMPROVING the treatment of arthritic hips. He TREATS impingement OF THE HIP, NOW CONSIDERED A MAJOR cause of osteoarthritis of the hip. HE has started a series of ARTHROSCOPIC procedures to remove the causes of impingement and conserve the natural tissues of the hip joint. MERELY conserving the tissue does not regrow ANY cartilage that has already been lost. Dr. Dunn HAS THEREFORE added IAGH treatment to regrow the cartilage that was damaged by impingement. HE CONTINUES to preserve the natural tissue and avoid total joints. His "BiologicArthroplasty" WITH IAGH is a 21st Century treatment.

THE DISCOVERY OF IAGH Dr. Alan Dunn
Allan R. Dunn, M.D. is an board certified Orthopedic Surgeon, AND RESEARCH SCIENTIST. HE discovered THE IAGH method to regenerate articular cartilage in 1965. After many years of research on laboratory animals to demonstrate the efficacy and safety of the IAGH method, Dr. Dunn, in 1998, started to treat patients with arthritis OF THE KNEE in an FDA approved study.
Every patient who has come for IAGH treatment has moderate to advanced arthritis and they have been told they need a joint replacement. They want IAGH treatment in order to avoid total joint surgery. Most patients are happy with their results after IAGH treatment BECAUSE THEY no longer NEED total joint surgery. MOST patients return to normal activities.

PUBLICATIONS:
Morphoangiogenesis: A UNIQUE ACTION OF GROWTH HORMONE in Microvascular Research 63:295-303,2002; this website IAGH.com; 2 U.S. patents and 2 European multination patents). Call our office and speak to Susan who can answer your questions.

MORPHO-ANGIOGENESIS
Morpho-angiogenesis is a unique benign action of growth hormone discovered by Dr. Dunn. He lectured on his discovery at Harvard University Medical School October 4, 2001. Morpho-angiogenesis causes rejuvenation of adult blood vessels to form fetal blood vessels which produce stem cells.
The IAGH method works because it utilizes this unique action of growth hormone. This action is a growth hormone dependent form of angiogenesis which leads to articular cartilage regeneration. Regular angiogenesis is a benign process in which new blood vessels develop and help produce new tissue. It occurs, for instance, after your skin is cut. In regular angiogenesis NEW BLOOD VESSELS develop from existing blood vessels.
Morphoangiogenesis is different because it forms structures AND BLOOD VESSELS. These new structures have one special function - which is to produce stem cells followed by production of new cartilage cells. Because THE MORPHOLOGY (anatomical structure) of the vessels has changed, Dr. Dunn gave the process a special name, Morpho-angiogenesis. These new structures are IDENTICAL to the structures which produce cartilage in the fetus.

FETAL SURGERY - produces scar-free healing!

Developmental pre-natal healing
When you understand fetal healing of skin, muscle and cartilage, you will better appreciate the IAGH method. Scar does not occur in fetal surgery because healing follows the Developmental Cascade, where inflammation is absent. The results of fetal surgery dealing with skin and muscle have never been transposed into adults.
Fetal healing of cartilage has been transposed to adults, and is a major step forward in arthritic treatment - IAGH.

POST NATAL HEALING:
The other form of healing is the POST NATAL HEALING. It is the familiar result of all surgeries now, FOR EXAMPLE- the appendix scar. This form of healing is ALWAYS associated with inflammation. and ALWAYS produces scar IN SKIN, and scar - fibro-cartilage IN JOINTS.

Summary:
IAGH Healing
IAGH healing follows the Developmental Cascade. There is no inflammation. Healing with IAGH grows new cartilage with no scar (articular cartilage). All the other methods to repair cartilage follow the POST-NATAL Cascade and THEY produce scar - fibrocartilage.
  • IAGH IS AT THE CUTTING EDGE OF MEDICAL SCIENCE.
  • IAGH UTILIZES YOUR BODY'S OWN STEM CELLS TO REGROW ARTICULAR CARTILAGE.
  • THE IAGH PROCESS IS SCIENCE-BASED FOLLOWING 30+ YEARS OF RESEARCH.
  • IAGH IS A PROVEN ALTERNATIVE TO TOTAL JOINT REPLACEMENT
  • IAGH IS PATENTED IN THE U.S.A. & EIGHT EUROPEAN COUNTRIES.

IAGH is the first instance where fetal healing has been transposed to the treatment of adults with arthritis. IAGH is the "Gold Standard" OF CARTILAGE HEALING.





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